Prodigal Summer weaves together three stories of human love within a larger tapestry of lives in southern Appalachia. At the heart of these intertwined narratives is a den of coyotes that have recently migrated into the region. Deanna Wolfe, a reclusive wildlife biologist, watches them from an isolated mountain cabin where she is caught off-guard by Eddie Bondo, a young hunter who comes to invade her most private spaces and her solitary life.